If:
$f(\pi) = a_n *\pi^n + a_{n-1} *\pi^{n-1}... a_1 *\pi$
and
$g(e) = b_n *e^n + b_{n-1} *e^{n-1}... b_1 *e$
$f(\pi) <> 0$, and $g(e) <> 0$
where $a_n$'s and $b_n$'s are whole or rational numbers. the powers also can be whole or rational numbers. for example: $f(\pi) = \frac{1}{3} *\pi^\frac{4}{7}+\pi^\frac{1}{10}$
Is it possible that $\frac{f(\pi)}{g(e)} = \frac{n}{m}$ (rational number)
IMO If we have whole powers it is impossible to get a rational result, but if we can use rational powers I'm not sure.
Your first question is very difficult to proof maybe. It is still not known whether this is true, if you still want to have a look, you may see https://www.reddit.com/r/math/comments/42zosg/is_pie_irrational/
But here is an interesting thing i found on this site. If you consider the polynomial $x^2+(\pi+\frac{1}{e})x+\frac{\pi}{e}=(x-\pi)(x-\frac{1}{e})$. This polynomial must have at least one irrational coefficient.
Now, $\frac{e}{\pi}$ is in this, and also, a number is transcedental if its reciprocal is.