It is asked to show that the closed disk $\overline{D}^2=\{(x,y)\in \Bbb{R}^2:x^2+y^2\leq 1\}$ (with the topology induced from $\Bbb{R}^2$) is not a regular surface.
It seems obvious that we have a problem already at the topological level (not needing to go into differentiability): $\overline{D}^2$ has nonempty boundary.
It is pretty pictoric that we can't have a homeomorphism between an open set from $\Bbb{R}^2$ and an open set containing a point from the boundary, but is there a way to prove this rigorously and by simple means?
This question has already been done here and here but, in the first, the answer is not very satisfactory and, in the second, there is no answer at all, only a comment.
Maybe the following is at stake:
What is the intrinsic definition of boundary?
Because if the definition of the boundary of $X$ is $\partial X:=\overline{X}\backslash \overset{\circ}{X}$, if $X$ is the universe set then always $\partial X=\overline{X}\backslash \overset{\circ}{X}=X\backslash X=\emptyset$... which is unpleasant...
I would suggest that a point $p\in X$ is said to be at the boundary if, there is no closed path $\gamma:S^1\to X$ "surrounding $p$". I mean, there is no closed path, determining a simply connected region in $X$ such that $p$ is this region, but not over the trace $\gamma(S^1)$. Is this correct? How to make this more precise? What rigourously would mean "to determine a region", etc?
EDIT: I was thinking also if the following definition works (for the bidimensional case): a point $p\in X$ is said to be in the boundary of the space $X$ if there is a simply connected neighborhood $N$ of $p$ such that $N-\{p\}$ is also simply connected.
First of all, I think it's appropriate to stress that the notion of boundary for (subspaces of) topological spaces is different of that for topological/smooth manifolds. A canonical example (as you already discussed in the comments) is the open ball, which has empty boundary as a manifold, but has the sphere as boundary as subspace of the euclidean space. Another easy example is that the topological boundary, because the definition involves an ambient space, is aways empty for the ambient itself (as you already mentioned too).
For the manifold case, the notion is clearly defined intrinsically, and your intuition with the homotopy groups is on spot, but it's easier to work with the relative homology groups instead (the geometric intuition is the same):
$x \in \text{Int}(M)$ if and only if $H_n(M,M-x;\mathbb{Z}) \approx \mathbb{Z}$;
$x \in \partial M$ if and only if $H_n(M,M-x;\mathbb{Z}) \approx 0$.
but it only works because topological manifolds are very well-behaved spaces.
The definition of the topological boundary makes sense only for subspaces, but its preserved by homeomorphisms: if $f:X\to Y$ is a homeomorphism, then $f(\partial(A))=\partial(f(A))$ for every $A\subset X$, so it's natural. It will depend now on what you understand by intrinsic.