To be more precise, fix a probability space $(\Omega,\mathcal{F},\mathbb{P})$, and let $X:\Omega\to\mathbb{R}$ be an $L^1$ random variable. Suppose $\Sigma\subset\mathcal{F}$ is such that $\mathbb{E}[X\mid\Sigma]=0$, then is $X$ independent of $\Sigma$?
This is true in the trivial cases where $\Sigma=\{\emptyset,\Omega\}$ or $\mathcal{F}$.
Let $X\sim N(0,1)$ and $Y\ge 1$ a.s. is any r.v. independent of $X$. Then $$ \mathsf{E}[(X/Y)\mid \sigma(Y)]=0=\mathsf{E}[X/Y] \quad\text{a.s.} $$ but $(X/Y)$ is not independent of $\sigma(Y)$.