I do not know too much about linear operators so forgive me if this doesn't make much sense, but what would the space of linear operators on $C^\infty[a,b]$ be defined as?
If we denote this space as $L(C^\infty[a,b])$ what can we say about it? Since $C^\infty[a,b]$ is a Frechet space is $L(C^\infty[a,b])$ also a Frechet space? What would be a useful norm (seminorms?) on $L(C^\infty[a,b])$? Given a norm or seminorms could you then talk about sequences of operators and their convergence?
Also given that the space $L(C^\infty[a,b])$ exists would the space of linear differential operators on $C^\infty[a,b]$ be a subspace of $L(C^\infty[a,b])$?
The space $L(C^\infty[a,b])$ of continuous linear operators on $C^\infty[a,b]$ is - excepting the trivial case $a = b$ - not a Fréchet space (in the usual topologies).
The usual topologies on $L(C^\infty[a,b])$ are
The seminorms generating the respective topology would be
$$p_{q,M}(T)=\sup\{q(Tx):x\in M\},$$
where $q$ is a continuous seminorm on $C^\infty[a,b]$, and $M$ ranges over the family of subsets of $C^\infty[a,b]$ under consideration, bounded, compact, or finite.
These topologies are not metrizable, since there is no countable basis of bounded/compact/finite sets in $C^\infty[a,b]$, hence no countable subset of seminorms generates the topology.
The space of linear differential operators (with smooth coefficients) is a subspace of $L(C^\infty[a,b])$, since such an operator is a continuous linear operator on $C^\infty[a,b]$.