Statement
If $U$ is open and $\text{int}(S)\neq\emptyset$ then $\text{int}(U\cap S)\neq\emptyset$ too when $U\cap S\neq\emptyset$ and when $S$ is path connected.
We know that $\text{int}(U\cap S)=\text{int}(U)\cap\text{int}(S)=U\cap\text{int}(S)$ so that if $\text{int}(U\cap S)=\emptyset$ and $U\cap S\neq\emptyset$ then $(U\cap S)\subseteq\text{Bd}(S)$ but unfortunately I don't see in this any contradiction. So I don't be able to prove the statement. Could be that it is generally false? Anyway it seems to me that in the case where $U$ and $S$ are path connencted subset of $\Bbb R^n$ then the statement holds so I think that although it is gerenally false it could be true if we consider some particular case. If it is more difficul understand when the statement is generally true I ask to prove it when $U$ and $S$ are subset of $\Bbb R^n$. Finally I point out that the statement is generally false when $U$ or $S$ are not path connected: e.g. if you take $U=(0,1)$ and $S=\{\frac 1 2\}\cup(2,3)$ or $U=\big[(0,1)\cup(2,3)\big]$ and $S=[1,2]$ then the statement is clearly false!
So could someone help me, please?

Connectedness problems often degenerate in $\Bbb R$, it's the plane where stuff gets interesting.
$U=\{x\mid \|x\|< 1\}$ which is open, path-connected.
$S= \{x \mid \|x\|\ge 1\} \cup \{(x,y):xy=0\}$, the exterior plus axes, clearly $U \cap S \neq \emptyset$ and the interior of $S$ is $\{x\mid \|x\| > 1\} \neq \emptyset$. $S$ is path-connected, and $S \cap U$ has empty interior (but is path-connected).