[There's still the strategy to go. A suitably robust argument that establishes what is statistically the best strategy will be accepted.]
Here's my description of the game:
There's a $4\times 4$ grid with some random, numbered cards on. The numbers are either one, two, or multiples of three. Using up, down, left, and right moves, you add the numbers on adjacent cards to make a new card like so: $$\begin{align}\color{blue}1+\color{red}2&=3\tag{1} \\ n+n&=2n\end{align}$$ for $n=2^k3\ge 3$, where $k\in\{0, 1, . . . , 10\}$, so the highest a card can be is $2^{11}3$. But at each move the "free" cards move too and a random new card appears at a random point along the edge you slide away from. Everything is kept on the grid. The card for the next move is indicated by colour at the top of the screen: blue for $1$, red for $2$, and white for $n\ge 3$ (such that $n$ is attainable using the above process). The white $2^\ell 3$-numbered cards are worth $3^{\ell+1}$ points; the rest give no points. Once there are no more available moves, the points on the remaining cards are summed to give your score for the game.
Here's another description I've found; it's the least promotional. It has the following gif.

So:
What's the best strategy for the game? What's the highest possible score?
Thoughts:
We could model this using some operations on $4\times 4$ matrices over $\mathbb{N}$. A new card would be the addition of $\alpha E_{ij}$ for some appropriate $\alpha$ and standard basis vector $E_{ij}$. That's all I've got . . .
NB: If this is a version of some other game, please let me know so I can avoid giving undue attention to this version :)
The number on each card can be written $n=2^k3^{\varepsilon_k}$, where $$\varepsilon_k=\cases{\color{blue}0\text{ or }1 &: $k=0$ \\ \color{red}0\text{ or }1 &: $k=1$ \\ 1 &: $k\ge 2$;}$$that is, $\varepsilon_k=\cases{0 &:$n<3$ \\ 1 &:$n\ge 3$}$. So we can write $(k, \varepsilon_k)$ instead under $$(k, \varepsilon_k)+(\ell, \varepsilon_\ell)\stackrel{(1)}{=}\cases{(k+1, 1)&: $\varepsilon_k, \varepsilon_\ell, k=\ell > 0$ \\ (0, 1)&: $\color{blue}k=\color{blue}{\varepsilon_k}=\color{red}{\varepsilon_\ell}=0, \color{red}\ell=1$ \\ (0, 1)&: $\color{blue}\ell=\color{red}{\varepsilon_k}=\color{blue}{\varepsilon_\ell}=0, \color{red}k=1$.}$$
Looking at a $2\times 2$ version might help: the moves from different starting positions show up if we work systematically. It fills up quickly.
It'd help to be more precise about what a good strategy might look like. The best strategy might be one that, from an arbitrary $4\times 4$ grid $G_0$ and with the least number of moves, gives the highest score attainable with $G_0$, subject to the random nature of the game. That's still a little vague though . . .
A partial answer:
The highest possible score is $16\times 3^{12}$.
If the game could start with no available moves, then just suppose it starts with $2^{11}3$ everywhere.
Alternatively, suppose you start with $2^{11}3$ in the top left and suppose every new card happens to be $2^{11}3$. Assume the cards all show up in the top left corner, which we can do in the following. Slide right until the top row is full. Slide down once. Repeat. This will eventually fill the grid; once it does, there'll be no more available moves so the game ends (with a score of $16\times 3^{11+1}$).