I am trying to use De Moivre–Laplace theorem to approximate $$1 - \sum_{k=0}^{n} {n \choose k} p^{k}(1-p)^{n-k} \log\left(1+\left(\frac{p}{1-p}\right)^{n-2k}\right)$$
The idea of an approximation is that we don't have the sum term which is difficult to calculate if $n$ is high.
Using the De Moivre–Laplace theorem gets us that: $${n \choose k} p^{k}(1-p)^{n-k} \approx \frac{1}{\sqrt{2 \pi np(1-p)}}e^{-\frac{(k-np)^2}{2np(1-p)}}$$ Now we see that \begin{align} F &= 1 - \sum_{k=0}^{n} {n \choose k} p^{k}(1-p)^{n-k} \log\left(1+\left(\frac{p}{1-p}\right)^{n-2k}\right) \\&\approx 1 - \int_{-\infty}^{\infty} \frac{1}{\sqrt{2 \pi np(1-p)}}e^{-\frac{(x-np)^2}{2np(1-p)}}\log_2\left(1+\left(\frac{p}{1-p}\right)^{n-2x}\right) dx \end{align}
my calculation is inspired by Entropy of a binomial distribution
If one has an other suggestion to approximate $F$ or get a closed for i would like to hear those. So far i've tried approximating $F$ with a least squares method using a tanh function as the fit function.
The expression looks very much like the Bernstein approximation of a function ($1-f(x)$) on $[0,1]$. But the argument (in fact the degree $n-2k$) of $log$ function ruins everything.
Here is a quick idea. Denote $$ y(p)=\sum_{k=0}^{n} {n \choose k} p^{k}(1-p)^{n-k} \log\left(1+\left(\frac{p}{1-p}\right)^{n-2k}\right). $$
Let us assume that we can represent $y(p)$ in the form $y(p)=\sum_{m=0}^\infty y_m p^m$, where $y_m$ are constants not depending on $p$.
Note that $y(p)=y(1-p)$. Let us consider the equation $$ y(p)+y(1-p)=f(p). \tag{eq1}\label{eq1} $$ Although we can write out the expression for $f(p)$, let us think that we don't know how $f(p)$ looks like. But for sure, $f(p)$ must satisfy $f(p)=f(1-p)$. It is know (see for example http://eqworld.ipmnet.ru/en/solutions/fe/fe1116.pdf) that equations like \eqref{eq1} have a solution, for example, $$ \tag{eq2}\label{eq2} y(p)=f(p) \sin^2({\pi p \over 2}). $$ By expanding $\sin^2({\pi p \over 2})$ into the Maclaurin series we get $$ y(p)=f(p) \sum_{m=1}^\infty {(-1)^{m+1} 2^{2m-1} \over (2m)!} {p^{2m} \pi^{2m} \over 2^{2m}}. $$
Let us assume that $f(p)$ is an analytic function i.e. $f(p)=\sum_{m=0}^\infty {f^{(m)}(0)\over m!} p^m$. By writing \eqref{eq2} in the series form we have: $$ \sum_{m=0}^\infty y_m p^m = \left ( \sum_{m=0}^\infty {f^{(m)}(0)\over m!} p^m \right ) \left ( \sum_{m=1}^\infty {(-1)^{m+1} \over (2m)!} {p^{2m} \pi^{2m} \over 2} \right ). $$
From this relation it may be possible to find the expressions for $f^{(m)}(0)$ through $y_m$ by equating the coefficients at $p^m$. If this works out, we go back to the right part of \eqref{eq2} and try to find how many terms in the product $$ \left ( f^{(0)}(0) + f^{(1)}(0) p + f^{(2)}(0) {p \over 2} + \dots \right ) \left ( \sum_{m=1}^\infty {(-1)^{m+1} \over (2m)!} {p^{2m} \pi^{2m} \over 2} \right ). $$
yield the approximate value.