Problem history:
I am working on calculating the probability of selecting at least $k$ $x$-cost cards in the creation of a deck in Hearthstone, a trading card game. In a certain game mode called Arena you have to choose $30$ times between three randomly selected cards to construct a deck. Picks $1$, $10$, $20$, and $30$ are special and the other picks are normal. Every card in Hearthstone has a cost; if I'm for example interested in cards with a cost of $2$, then I can calculate the probability that I will get the card offered in a single pick by calculating the ratio of $2$-cost cards versus all the offered cards. Suppose the probability for normal picks is $p_n$ and the probability for special picks is $p_s$.
Problem translation:
We can actually ask the above question at any point in the picking, so there may be less cards than $30$ remaining.
We have the following random variables as an example when we still have all $30$ picks remaining:
$$X\sim\text{Binom}(26, p_n),$$ $$Y\sim\text{Binom}(4, p_s).$$
As another example we can take the case of having completed $10$ picks, so there are $20$ remaining, then:
$$X\sim\text{Binom}(18, p_n),$$ $$Y\sim\text{Binom}(2, p_s),$$
because picks $1$ and $10$ were special picks, there's $20$ picks remaining, and picks $20$ and $30$ are also special.
We want to know the probability of picking at least $k$ $x$-drops in $X$ and $Y$ combined.
New problem statement:
To decouple our original problem statement from Hearthstone, I thought a translation to a die experiment would be useful.
I think the new problem statement is the following:
What is the probability of throwing at least $k$ ones when throwing $n$ fair six-sided dice and $m$ fair eight-sided dice?
Of course I have thought about the solution, but it seems to be an ugly case distinction, and I feel that there should be a better solution.
Not sure if there would be a neat closed form expression for this. However, we essentially want to sum up the probabilities of all events in which $k_6 + k_8 \geq k$, where we define $k_6$ as the number of ones rolled from the $n$ six-sided dice, and $k_8$ as the number of ones rolled from the $m$ eight-sided dice. This definition yields:
$$\sum_{k_6 + k_8 \geq k}{\left(\binom{n}{k_6}\cdot\left(\frac{1}{6}\right)^{k_6}\cdot\left(\frac{5}{6}\right)^{n - k_6}\cdot\binom{m}{k_8}\cdot\left(\frac{1}{8}\right)^{k_8}\cdot\left(\frac{7}{8}\right)^{m - k_8}\right)}.$$
Equivalently, we could write:
$$\sum_{k_6 = 0}^{n}{\left(\binom{n}{k_6}\cdot\left(\frac{1}{6}\right)^{k_6}\cdot\left(\frac{5}{6}\right)^{n - k_6}\cdot\sum_{k_8 = k - k_6}^{m}{\binom{m}{k_8}\cdot\left(\frac{1}{8}\right)^{k_8}\cdot\left(\frac{7}{8}\right)^{m - k_8}}\right)}.$$
Will continue to think about more concrete expressions for this. Hope this helps!