Consider the illustrated binomial (not binary) tree with $n$ steps (drawn for $n=5$, but consider $n$ variable). Start a random walk at the left-hand node, and at each step you have probability $p$ of visiting the node to your lower-right, and probability $1-p$ of visiting the node to your upper-right.
What's the probability, call it $P_n$ (or whatever else you like:), of completing an $n$-step walk without ever visiting any node above the dotted-line baseline, i.e., never visiting one of the labelled "prohibited nodes". You're allowed to visit nodes "touching" the baseline (possible on even-numbered steps only), but never nodes above it.
Edit #3 (new binomial coeff identity???)
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@BrianTung answered the question below, and below that I added another "answer", just numerically confirming Brian's result, based on his $_nD_k$ "modified binomial coefficients" (see Brian's answer). And I subsequently modified that program, just to see if my original effort at an answer, based on my $N^m_n$ coefficients (see Edit#2 below), might also work. Kind of surprised me to find that my answer works, too.
And what just occurred to me is that since both answers involve exactly the same (somewhat modified) cumulative binomial distribution sum of the form $\sum_k \mbox{coef}_{n,k}p^k(1-p)^{n-k}$, therefore both our coefficeints must be identical. And (after juggling my non-standard $m,n$-notation in $N^m_n$ to Brian's standard $n,k$'s) that leads to the following necessary-but-goofy-looking identity, $$ \frac{n-2k+1}{n-k+1}\binom{n}{k} = \binom{n-1}{k} \ - \ \sum_{i=1}^{k-1} i\ \binom{n-i-2}{k-i-1}, \hspace{10pt} k\leq\frac n2$$ where Brian's $_nD_k$ is on the lhs and mine's on the rhs. Just to be sure, I numerically checked it, and it's correct. And maybe it algebraically simplifies to some common binomial coefficient formula, but I'm not seeing how to do that. And if it doesn't simplify, then you probably "saw it here first":).
Motivation
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Firstly, much thanks to @saulspatz and @BrianTung for their elaborate effort replying to this question. So I thought I should add a paragraph explaining why I'd asked it (beyond recreational). That relates to the comment link https://en.wikipedia.org/wiki/Binomial_options_pricing_model I posted below ( chiding :) @jorwiki for his terminology usage formality ). Anyway...
The purpose is pricing (getting the current value of) cashflows from consumer mortgages along a binomial tree of interest rates (determined from treasury notes and bonds, and from a given volatility parameter). But mortgages are like options due to prepayments, e.g., if you sell your house then you typically pay off the entire mortgage and all cashflows abruptly stop. Statistics for that kind of prepayment are pretty much actuarially determined from observed behaviors. But if interest rates go down a lot, people may choose to refinance their mortgages to take advantage of lower monthly payments (after accounting for refinance costs, etc). That's called "rational exercise", although prepayment models usually model plenty of not-so-rational behavior, too.
So the "baseline" here represents rational exercise -- the rate below which the mortgage is refinanced and cashflows stop. The actual model's on a computer, and this idealized closed-form solution is therefore irrelevant. But for testing and comparison purposes, it's a useful tool to have. Of course, however, I seem to have underestimated the number-theory-type stuff required for that solution :)
EDIT#1 (some preceding work)
---------------------------------------------
As per @saulspatz's comment request below, I'm showing some work I'd already tried. But it's just to demonstrate that I tried. Don't actually try reading it too carefully. It's not well-written, and in the end it didn't lead much of anywhere.
For $p=.5$ I tried arguing heads/tails "paths", somewhat along the following lines.
tails<----- oN00 ----->heads
/ \
+-------------------------------+ / \ +--------------------------------+
| Nht denotes number of "legal"/ oN01 o \An "illegal" path on the right |
| paths from N00 to the node / / \ / \ \ side of the tree has more |
| representing h heads and / / \ / \ \ heads than tails before the |
| t tails. "Legal" paths / oN02 oN11 o \ n-th trial. The lower |
| must stay within the / / \ / \ / \ \ left of the tree has |
| labelled portion / / \ / \ / \ \ too many tails to |
| of the tree. / oN03 oN21 o o \ catch up by n. |
+-----------------------+ / \ / \ / \ / \ +------------------------+
/ \ / \ / \ / \
oN04 oN13 oN22 o o
/ \ / \ / \ / \ / \
/ \ / \ / \ / \ / \
oN05 oN14 oN23 o o o
/ \ / \ / \ / \ / \ / \
/ \ / \ / \ / \ / \ / \
oN06 oN15 oN24 oN33 o o o
For any $N^0_t$, note that $N^0_1=N^0_2=\cdots=1$ since there's only one possible path along the ``left edge'' of the tree, i.e., toss all tails).
For $N^1_6$, there's exactly one path from $N^0_6$ to $N^1_6$, one path from $N^0_5$ to $N^1_6$ ($N^0_5\rightarrow N^1_5\rightarrow N^1_6$) in addition to the preceding path through $N^0_6$, one path from $N^0_4$ to $N^1_6$ ($N^0_4\rightarrow N^1_4\rightarrow N^1_5\rightarrow N^1_6$) in addition to the preceding paths, $\ldots$, and, finally, one additional path from $N^0_1$ to $N^1_6$ (there are no additional paths from $N^0_0$ to $N^1_6$).
By similar reasoning we obtain the following sequence of
iterative formulas:
$N^1_6$ = $N^0_6$ + $N^0_5$ + $N^0_4$ +
$N^0_3$ + $N^0_2$ + $N^0_1$
$N^2_6$ = $N^1_6$ + $N^1_5$ + $N^1_4$ +
$N^1_3$ + $N^1_2$
$N^3_6$ = $N^2_6$ + $N^2_5$ + $N^2_4$ + $N^2_3$
$N^4_6$ = $N^3_6$ + $N^3_5$ + $N^3_4$
$N^5_6$ = $N^4_6$ + $N^4_5$
$N^6_6$ = $N^6_6$
For "interior" nodes, the same reasoning applies,
e.g.:
$N^3_5$ = $N^2_5$ + $N^2_4$ + $N^2_3$
etc.
For the general case we therefore conclude:
$N^m_n$ = $\sum_{k=m}^n N^{m-1}_k$
= $\sum_{k=1}^n N^{m-1}_k$
$-$ $\sum_{k=1}^{m-1} N^{m-1}_k$
with $N^0_n=1$ (and, trivially, $N^1_n=n$).
EDIT#2 (some recurrence relations)
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Following along with @BrianTung's work below, I'm posting some recurrence relations that seemed to be useful while I was trying to find a closed-form solution for my $N^m_n$. I'll continue using my notation rather than Brian's pretty-much-corresponding ${}_nD_k$, just so I can transcribe my notes with hopefully minimal mistakes...
Firstly, a generalization of the usual $\sum_1^ni=\frac{n(n+1)}2$,
define $H^m_n$ as follows,
$ \begin{array}{cclcl}
H^1_n & = & & & \mbox{$1$ for all $n$} \\
H^2_n & = & \sum_{i=1}^n H^1_i & = & n \\
H^3_n & = & \sum_{i=1}^n H^2_i & = & \frac{n(n+1)}{2!} \mbox{as usual}\\
H^4_n & = & \sum_{i=1}^n H^3_i & \stackrel{?}{=} &
\underbrace{an^3+bn^2+cn}_{
\mbox{solve for $a,b,c$ $\ldots$}} \\
& & & = & \frac{1}{6}n^3 + \frac{1}{2}n^2 + \frac{1}{3}n \\
& & & = & \frac{n(n+1)(n+2)}{3!} \\
\end{array}$
Now, by examination we infer the general expression
$\begin{array}{ccl} H^m_n & = & \frac{1}{(m-1)!} \prod_{k=1}^{m-1} (n+k-1) \\ & = & \frac{(n+m-2)!}{(m-1)!(n-1)!} \\ & = & \binom{n+m-2}{m-1} = \binom{n+m-2}{n-1} \\ \end{array}$
So now a closed-form solution for $N^m_n$ can tentatively be developed from our earlier (from Edit#1)
$N^m_n$ = $\sum_{k=m}^n N^{m-1}_k$
= $\sum_{k=1}^n N^{m-1}_k$
- $\sum_{k=1}^{m-1} N^{m-1}_k$
by using the above $H^m_n$ formula to iteratively evaluate...
$\begin{array}{cclclclcl} N^0_n &=& 1 \\ &\equiv& H^1_n \\ N^1_n &=& \sum_{k=1}^n N^0_k - \underbrace{\sum_{k=1}^0 N^0_k}_{=0} \\ &=& \sum_{k=1}^{n} H^1_n \\ &=& H^2_n \\ N^2_n &=& \sum_{k=1}^n N^1_k - \sum_{k=1}^1 N^1_k \\ &=& \sum_{k=1}^n H^2_k - \sum_{k=1}^1 H^2_k \\ &=& H^3_n - \underbrace{H^3_1}_{=1=1H^1_n} \\ &=& H^3_n - H^1_n \\ N^3_n &=& \sum_{k=1}^n(H^3_k - H^1_k) - \sum_{k=1}^2(H^3_k - H^1_k) \\ &=& (H^4_n -H^2_n) - \underbrace{(H^4_2 - H^2_2)}_{=2=2H^1_n} \\ N^4_n &=& (H^5_n - H^3_n - 2H^2_n) - \underbrace{(H^5_3 - H^3_3 - 2H^2_3)}_{=3=3H^1_n} \\ N^5_n &=& (H^6_n - H^4_n - 2H^3_n - 3H^2_n) - \underbrace{(H^6_4-H^4_4-2H^3_4-3H^2_4)}_{=4=4H^1_n} \\ \vdots \\ N^m_n &=& H^{m+1}_n - \sum_{k=1}^{m-1} kH^{m-k}_n \\ & & \mbox{iff for any integer $m$ we have } m \stackrel{?}{=} H^{m+2}_m - \sum_{k=1}^{m-1} kH^{m+1-k}_m\\ & & \mbox{which seems to work out for the cases I tested} \end{array}$

ETA2: I rolled back, because the OP's notation is a little different from mine. OP uses $_mN_k$ for the number of ways for $k$ upward moves to be chosen out of $k+m$ total moves; I use $_nD_k$ for the number of ways for $k$ upward moves to be chosen out of $n$ total moves.
Partial answer. It occurs to me that one can proceed as one normally does with the binomial distribution, but one must use different coefficients. Whereas the normal binomial coefficients $_nC_k$ have a recurrence of
$$ _nC_k ={} _{n-1}C_{k-1} +{} _{n-1}C_k $$
our modified coefficients $_nD_k$ have a recurrence of
$$ _nD_k = \begin{cases} _{n-1}D_{k-1} +{} _{n-1}D_k & k \leq n/2 \\ 0 & \text{otherwise} \end{cases} $$
Once this is done, it seems to me that we can compute
$$ P(\text{permissible path of length $n$}) = \sum_{k=0}^{\lfloor n/2 \rfloor} {} _nD_k (1-p)^k p^{n-k} $$
A little pencil-and-paper noodling and trawling on OEIS seems to show that
$$ _nD_k = \frac{n-2k+1}{n-k+1} \binom{n}{k} $$
Note that this puts the Catalan numbers right on the critical line. I still have to figure out $_nD_k$ from first principles, though.