Please apologize the question, I struggled with finding a good formulation in the first place:
Looking at $\binom{2n}{k}$ it is very clear that for n,k integer and n>k we can solve it by calculating:
$$(2n)!\over k!(2n-k)!$$
$2n!$ is clearly not the same as $(2n)!$ as for $n=3$ we easily see $2\times3\times2\times1 \neq 6\times5\times4\times3\times2\times1$
Which mathematical rule is responsible for this? I mean it is clearly just a substitution, but still I struggle in finding any ruling for this differentiation - probably because it is as basic.
The standard notation for the factorial function is rather unusual.
Usually we define a function $f$ from space $A$ to space $B$ by saying $f: A\rightarrow B$ and then whenever we write the function we (usually) require parentheses to describe precisely what the function operates on, so $2f(a)$ and $f(2a)$ mean clearly different things. In the order of operations you apply parentheses first and then apply all functions (the introductory form of the order of operations: PEMDAS can be broadened to include all functions in the E for exponentiation - all functions would take the same precedence as exponentiation in an analogous way to how the M for multiplication and D for division take the same precedence as each other).
The "$!$" notation is usually taken as a function whose argument is the variable or constant which is written directly in front of it.
You might be interested in further reading: Most ambiguous and inconsistent phrases and notations in maths.