There is this puzzle called Chomp. You can play and read about it here if you don't know it:
https://www.math.ucla.edu/~tom/Games/chomp.html
It is well-known that Chomp has a winning strategy for the first player, except for the case of $1*1$. The proof is brilliant, but it is non-constructive, using a strategy-stealing argument.
Imagine you are playing it with friends, who don't know about the winning strategy. He can be the first player, but he doesn't necessarily play the best move. Then, how should you respond? Is there a good strategy/heuristic to help us win?

I haven't analyzed it for the strategy, but the page source on your link has the java script it uses to find moves:
Edit: Here are the winning 4 by 7 positions encoded or mentioned in the comment: