The construction that I had in mind was:
Let $X$ be an uncountable space. We'll assume it has just one countable dense subset $E$. Let points $p_{1},p_{2}\in X\setminus E$ such that every open set containing either of the two points contains some or all points $a_{1},a_{2}\dots a_{n}\in E$. Then the space $X-\{ a_{1},a_{2}\dots a_{n}\}$ won't have a countable dense subset, as $E-\{ a_{1},a_{2}\dots a_{n}\}$ won't have $p_{1},p_{2}$ in its closure.
Am I making too many assumptions?
Thanks for your time!
This may not warrant an answer, but here are couple observations.