It is clear that $Y \perp X | Z \implies \mathbb{E}[Y|X,Z] = \mathbb{E}[Y|Z]$ almost surely,but does the reverse implication always hold?
2026-04-28 12:18:40.1777378720
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Does $\mathbb{E}[Y|X,Z] = \mathbb{E}[Y|Z]$ almost surely imply $Y \perp X | Z$
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$\mathbb{E}[Y\mid X] = \mathbb{E}[Y]$ does not imply $Y \perp X $
so conditioning on $Z$ is just as unsatisfactory
Consider the following equally likely sets of values each with probability $\frac18$
X Y Z
1 1 3
1 5 3
2 2 3
2 4 3
1 3 5
1 7 5
2 4 5
2 6 5
You find $\mathbb{E}[Y\mid X,Z] = Z = \mathbb{E}[Y\mid Z]$, but $X$ determines the parity of $Y$ so they are not independent in any sense, conditional or otherwise
As the other answer mentions, the condition does not suffice. However, if you assume $E[f(Y)|X,Z] = E[f(Y)|Z]$ for all bounded measurable $f$, that does suffice.
Write for any bounded measurable $f,g$ that $$ E[f(Y)g(X) | Z] = E[E[f(Y)g(X)| X, Z]|Z] = E[g(X) E[f(Y)|X,Z]|Z] $$ $$ = E[g(X) E[f(Y)|Z] | Z] = E[g(X) | Z] E[f(Y)|Z]. $$ Thus we have $Y\perp X$ conditional on $Z$.