$\newcommand{\nest}{\operatorname{nest}}$Let's define a function $\nest(f, x, k)$, which takes a function $f$, an input $x$, and a non-negative integer $k$, and calls $f$ on $x$ repeatedly ($k$ times). For example, $$ \nest(f, x, 0) = x\\ \nest(f, x, 1)=f(x)\\ \nest(f, x, 2)=f(f(x))\\ \nest(f, x, 3)=f(f(f(x)))$$ Formally, this function can be written as $$ \nest(f, x, k)= \begin{cases} x & \text{if } k=0\\ \nest(f, f(x), k-1) & \text{otherwise} \end{cases}$$
For a given $k$ and a polynomial $p$, how can I find a function $f: \mathbb C \to \mathbb C$ such that $\nest(f, x, k)=p(x)$?
If it's not possible to do so in the general case, is it possible with $p(x)=c+x^2$?

You are really asking about functional iterates, normally denoted by $f^ n(x)\equiv \operatorname{nest}(f, x, n)$. I gather you are interested in problem solving methods over rigor.
They are normally obtained by functional iteration through Schröder's equation, but even your simple quadratic $p(x)=x^2+c$ does not have closed solutions, except, e.g., for $c=-2$, a "chaotic" logistic map , as you may see from the examples in the WP article linked above.
In that celebrated special case, a closed form (p302) was found by Ernst Schroeder himself (1870).
Namely, for
$$ p(x)= x^2-2, $$ it follows directly that for $$ y=\frac{x\pm \sqrt{x^2-4}}{2} $$ that is $$ x=y+y^{-1}, $$ one has $$ p(x)=y^2+y^{-2}\equiv p^1 (x). $$ Whence,
$$ p^n (x)= y^{2^n}+ y^{-2^n}. $$
More formally, in E.S.'s language of conjugacy, $$ \psi(p(x))=g(\psi(x)),\\ \psi(x)=\frac{x\pm \sqrt{x^2-4}}{2}\\ g(y)=y^2 \qquad \Longrightarrow \\ g^n(y)=y^{2^n};$$ so that $p(x)= \psi^{-1} \circ g \circ \psi (x)$, and $$p^n= \psi^{-1} \circ g^n \circ \psi ~.$$
I am restricting this to real variables and domains where the objects treated make sense. Your particular question $f^k (x)=x^2-2=p(x)$ then can produce $p^{1/k}(x)$ for suitable domains for you to explore. There are, of course, a plethora of solution-seeking texts on the subject, like C Efthimiou's Introduction to Functional Equations, AMS 2011, ISBN: 978-0-8218-5314-6 , online. A conjugacy iteration approximation method is available in our 2011 paper: Approximate solutions of Functional equations.