The sum of the angles on a straight line equal $180^\circ$.
The sum of the angles in a triangle is $180^\circ$.
In a isosceles triangle, the two base angles are the same.
For example, find $\angle BCD$ from the first hint, and $\angle BAC$ from the second. Continue writing all angles in terms of $x$ and $46^\circ$. At some point, you will get an equation relating the two.
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As stated, C lies between A and D, and E lies between A and B. But that is impossible. If you allow D to lie between A and C, or E to lie outside the segment AB, then $\angle ABC$ is not determined.
Hints: you will need to use the following:
For example, find $\angle BCD$ from the first hint, and $\angle BAC$ from the second. Continue writing all angles in terms of $x$ and $46^\circ$. At some point, you will get an equation relating the two.