So my first thought was to find the critical points of the $4x^2-4xy+y^2$ and I calculated. $$F_{x}=8x-4y,\quad F_{y}=2y-4x$$ and I found out that critical point are satisfying $x=2y$.
Then I put then to equation $x^2+y^2=25$. And I calculated that $x=\sqrt5,y=2\sqrt5$, and $x=-\sqrt5$, $y=-2\sqrt5$.
But I don't know if they are maximum or minimum.
My last idea was to to put $x^2=25-y^2 $ to the function $4x^2-4xy+y^2$ and then calculate the derivative. But I do not know if it is a good solution.
It's obvious that the minimum is $0$.
For $x=2\sqrt5$ and $y=-\sqrt5$ we get a value $125$.
We'll prove that it's a maximal value.
Indeed, we need to prove that $$(2x-y)^2\leq5(x^2+y^2)$$ or $$(x+2y)^2\geq0.$$ Done!