Mean difference

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I have two sets of sample data with the first one having the mean of

100.1

and the second set having the mean of

192.1

and if i were to find the mean difference between this two sets, how do i know which of the mean above should subtract with another mean?

For example, i could use the first set to subtract the second set mean

100.1 - 192.1 = -92

while i could use the second to minus the first:

192.1 - 100.1 = 92

I'm confused on which should minus which as i will then need to use the mean difference to calculate the 95% interval. Would love some advice on this.