I want to calculate the probability that some mutation occurs on a certain DNA section by a given number mutations. I rephrased it into this problem:
Three (identical) persons enter a train (section A has $5$ seats, section B has $8$ seats and section C has $2$ seats). What is the probability that exactly (not more or less) $2$ persons sit in section A? (all seats have the same probability)
Let's call the persons 1,2,3 and assume they enter in that order. The case you want to look at are 1-2 or 1-3 or 2-3 in section A while 3 in B or C, 2 in B or C, 1 in B or C.
It results that you don't even need to differentiate between B and C, so let's call it BC with 10 seats.
You have the $15 \times 14 \times 13 $ possible arrangements to begin with so the final answer if I did not make any silly mistake is $\frac{3\times5\times4\times10}{15 \times 14 \times 13 }$