I tried using the slope method, basically that $m_{1}\times m_{2}=-1$ and I got the relation that:
$\cos(\alpha-\beta)=0$
Clearly $\alpha-\beta=\pi/2$, i.e. $\sin(\frac{\alpha-\beta}{2})=(\frac{1}{\sqrt{2}})$
But one case which I think should also be considered is $\alpha-\beta=\frac{3\pi}{2}$, which would result in a negative value for $\cos(\frac{\alpha-\beta}{2})$, but the answer to the referenced image doesn't consider it. Why? (The answer given is (A) and (C))
$(0,0)$, B
All four answers are correct.
Notice the problem says "if", not "if and only if", so an answer is correct if its inequality implies that the triangle is a right triangle.
You are correct that the triangle is a right triangle if and only if $\cos(\alpha-\beta) = 0$.
We have the double angle formulas
$$ \cos(\alpha-\beta) = 2 \cos^2 \frac{\alpha-\beta}{2} - 1 $$ $$ \cos(\alpha-\beta) = 1 - 2 \sin^2 \frac{\alpha-\beta}{2} $$
By the first,
$$ \cos \frac{\alpha-\beta}{2} = \pm \frac{1}{\sqrt{2}} \implies \cos(\alpha-\beta) = 0 $$
By the second,
$$ \sin \frac{\alpha-\beta}{2} = \pm \frac{1}{\sqrt{2}} \implies \cos(\alpha-\beta) = 0 $$
So each of the four conditions is sufficient to show that the triangle is a right triangle. Of course, only two of them can be true for a single scenario, so these are not necessary conditions.