Suppose I have the following vector field $$\underline{G} = \frac{-y}{x^2+y^2}\underline{i}+\frac{x}{x^2+y^2}\underline{j}$$ this is clearly defined for $(x,y)\neq (0,0)$, i.e. the $z$ axis.
Suppose I want to find the work along the unit circle $C$ centred at the origin and lying on the plane $z=0$, parametrised as $\underline{r}(t) = \cos(t)\underline{i}+\sin(t)\underline{j}$ for $0\leq t\leq 2\pi$. Now if we calculate the line integral we see that $$\int_C\underline{G}\cdot d\underline{r} = 2\pi\neq 0$$
the reason I gave in the question was that this happens because the region inside the circle is not simply connected, indeed we cannot shrunk the circle to the origin!
Then I tried to show this even further and say, consider the unit circle centered at $(2,2)$ (so it doesn't contain the origin, nor the axes) then the work along $C_2 : \underline{r}_2(t) = (\cos(t)+2)\underline{i}+(\sin(t)+2)\underline{j}$ should be zero as the region there is simply connected! However it is not zero..
where did I go wrong? Are my assumptions wrong?
Edit

Yes, the integral on the unit circle around $\;(2,2)\;$ is zero, and the reason is simple: the vector field has a potencial function there:
$$\phi(x,y)=\arctan\frac yx$$
so the value of the integral around the unit circle centered at $\;(2,2)\;$ is zero...and in fact, over any closed, simple smooth curve not containing the origin.