I am familiar with the Radon-Nikodym Theorem and an R/N Derivative, but while reading a set of lecture notes on: Stochastic Calculus, Filtering, and Stochastic Control in section 1.6: "Induced measures, independence, and absolute continuity", (bottom of page 42, emphasis mine):
Absolutely continuous measures and the Radon-Nikodym theorem
Let $(\Omega, \mathcal{F}, \mathbb{P})$ be a given probability space. It is often interesting to try to find other measures on $\mathcal{F}$ with different properties. We may have gone through some trouble to construct a measure $\mathbb{P}$, but once we have such a measure, we can generate a large family of related measures using a rather simple technique. This idea will come in very handy in many situations; calculations which are difficult under one measure can often become very simple if we change to a suitably modified measure (for example, if $\{X_n\}$ is a collection of random variables with some complicated dependencies under $\mathbb{P}$, it may be advantageous to compute using a modified measure $\mathbb{Q}$ under which the $X_n$ are independent. Later on, the change of measure concept will form the basis form one of the most basic tools in our stochastic toolbox, the Girsanov theorem.
I'm having trouble conceptualizing the idea that "calculations which are difficult under one measure can often become very simple if we change to a suitably modified measure". Can someone further explain, perhaps by a couple examples, how this is the case? How can $X_n$ have complicated dependencies under $\mathbb{P}$, but simple (independent) dependencies under a $\mathbb{Q}$?
One example where a change of measure can make calculations simpler is the risk-neutral measure used commonly in finance.
Assume the price of a stock, $S_t$ satisfies the following SDE:
$$dS_t = \mu S_t dt + \sigma S_t dW_t$$
where $W_t$ is Brownian Motion. Using Girsanov's theorem, you can express the discounted stock price, $\tilde{S_t} = e^{-rt}S_t$ as
$$d\tilde{S_t} = \sigma \tilde{S_t}d\tilde{W_t}$$
Where $\tilde{W_t} = W_t + \frac{\mu - r}{\sigma} t$ is a martingale under a change of measure, $\mathbb{Q}$.
Under the original probability measure, $\mathbb{P}$, $\tilde{W_t}$ is not a martingale nor Brownian motion, but under the risk neutral measure, $\mathbb{Q}$, it is.
Since martingales have a lot of useful properties and are typically easier to manipulate than non-martingales, this is an example where the change-of-measure makes things easier.