If $(A,C)$ and $(B,D)$ are $\mathbb{P}$-independent, then it holds true that: $$\mathbb{P}(A\cap B | C\cap D) = \frac{\mathbb{P}(A\cap B \cap C\cap D)}{\mathbb{P}(C\cap D)} = \frac{\mathbb{P}(A\cap C)\mathbb{P}(B\cap D)}{\mathbb{P}(C)\mathbb{P}(D)} =\mathbb{P}(A|C)\mathbb{P}(B|D).$$ Now, I want to investigate this relation more deeply without assuming that $(A,C)$ and $(B,D)$ are $\mathbb{P}$-independent.
Suppose only that $A$ and $B$ are $\mathbb{P}(\cdot|C\cap D)$-independent. Then: $$\mathbb{P}(A\cap B | C\cap D)=\mathbb{P}(A | C\cap D)\mathbb{P}(B | C\cap D)=\frac{\mathbb{P}(A \cap C\cap D)}{\mathbb{P}(C\cap D)}\frac{\mathbb{P}(B \cap C\cap D)}{\mathbb{P}(C\cap D)}=(*).$$ Now, suppose also that $A\cap C$ and $D$ are $\mathbb{P}$-independent and $B\cap D$ and $C$ are $\mathbb{P}$-independent. Then: $$(*)=\frac{\mathbb{P}(A\cap C)\mathbb{P}(D)}{\mathbb{P}(C\cap D)}\frac{\mathbb{P}(B \cap D)\mathbb{P}(C)}{\mathbb{P}(C\cap D)}= \mathbb{P}(A|C)\mathbb{P}(B|D)\left(\frac{\mathbb{P}(C)\mathbb{P}(D)}{\mathbb{P}(C\cap D)}\right)^2,$$ and so we see that what it is missing to obtain the initial equation is requiring that $C$ and $D$ are $\mathbb{P}$-independent.
Now, I'm wondering if the assumed conditions alone imply that the initial equation holds, i.e. if:
- $A$ and $B$ are $\mathbb{P}(\cdot|C\cap D)$-independent;
- $A\cap C$ and $D$ are $\mathbb{P}$-independent;
- $B\cap D$ and $C$ are $\mathbb{P} $-independent;
- $\mathbb{P}(A\cap B | C\cap D)>0$;
is it true that $$\mathbb{P}(A\cap B | C\cap D) =\mathbb{P}(A|C)\mathbb{P}(B|D)?$$
I think that the answer is no, since if this is the case, the last equation implies the $\mathbb{P}$-indipendence of $C$ and $D$ also, and I suspect that this would be too much... I'm a bit lost finding a counter-example. Any help?
UPDATE Here is a "100% non-trivial" counter-example where every probability is neither $0$ nor $1$. :)
Sorry this is kinda tedious but it is the "smallest" such example I can think of. (If you allow some prob to be $1$ then smaller counter-examples exist.)
Uniformly draw a number from $\{1, 2, \dots, 24\}$ and define:
$C = \{1, 2, \dots, 12\}$ and $P(C) = 12/24 = 1/2$
$D = \{9, 10, \dots, 20\}$ and $P(D) = 12/24 = 1/2$
$C \cap D = \{9, 10, 11, 12\}$ and $P(C\cap D) = 4/24 = 1/6 \neq P(C)P(D)$, so they are dependent.
$A = \{1, 2, 9, 11\} = A \cap C, P(A\cap C) = 4/24 = 1/6$
$P(A\cap C \cap D) = P(\{9, 11\}) = 2/24 = 1/12 = P(A \cap C) P(D)$, so $(A\cap C) \perp D$
$B = \{9, 10, 19, 20\} = B \cap D, P(B \cap D) = 4/24 = 1/6$
$P(B\cap D \cap C) = P(\{9, 10\}) = 2/24 = 1/12 = P(B\cap D) P(C)$, so $(B \cap D) \perp C$
Finally, when conditioned on $C\cap D = \{9, 10, 11, 12\}$, we have (excuse my abuse of notation):
$P(A|C \cap D) = {\{9, 11\} \over \{9, 10, 11, 12\}} = 1/2$
$P(B|C \cap D) = {\{9, 10\} \over \{9, 10, 11, 12\}} = 1/2$
$P(A \cap B | C \cap D) = {\{9\} \over \{9,10,11,12\}} = 1/4$, so $A \perp B$ when conditioned on $(C \cap D)$.
Whew!
This "pictorial view" might be easier (pick one of $24$ squares uniformly randomly):
BTW your big equation becomes:
$$\frac14 = \frac13 \times \frac13 \times ({\frac12 \times \frac12 \over \frac16})^2$$
P.S. if you allow some prob to be $1$, specifically $P(A|C\cap D) = P(B | C\cap D) = P(A\cap B | C \cap D) = 1$, then a smaller example is the 2nd row above, i.e.
As the question is written, the answer is No, but the counter-example I have below is "trivial" and may not be what you have in mind:
$A=B=\emptyset$, i.e. the empty set (the impossible event)
$C=D$ and $P(C) = P(D) > 0$
Your big equation reduces to $0 = 0 \times ({P(C)P(D) \over P(C \cap D)})^2$ which is trivially true even if $P(C)P(D) \neq P(C\cap D)$, i.e. even if $C, D$ are dependent.